Prognostic implications of epigenetic silencing of p15INK4B in acute promyelocytic leukemia

@article{GarcaManero2003PrognosticIO,
  title={Prognostic implications of epigenetic silencing of p15INK4B in acute promyelocytic leukemia},
  author={Guillermo Garc{\'i}a-Manero},
  journal={Leukemia},
  year={2003},
  volume={17},
  pages={839-840}
}
In this issue of Leukemia, Teofili et al report the prognostic value of aberrant DNA methylation of the p15 gene in acute promyelocytic leukemia (APL). Cytosine guanine (CpG) pairs are under-represented in the human genome except in areas known as CpG islands where their frequency is near that of predicted. CpG islands can be found in the proximity of gene… CONTINUE READING