Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung.

@article{Kim2005PrognosticIO,
  title={Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung.},
  author={Young Tae Kim and Sun Jung Park and Seung Hee Lee and Hee Jung Kang and Seokyung Hahn and Chang Hyun Kang and Sook Whan Sung and Jeonghyun Kim},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2005},
  volume={130 5},
  pages={
          1378
        }
}
OBJECTIVES DNA hypermethylation in promoter regions has been studied for various types of cancer. However, there is no clear evidence that shows whether methylation status can predict long-term survival in patients with lung cancer. METHODS We collected tissues from 72 patients with lung adenocarcinomas. The cancer and normal lung tissues were tested for DNA hypermethylation by using methylation-specific polymerase chain reaction. The genes investigated were p16INK4alpha(p16), retinoic acid… CONTINUE READING
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