Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma.

@article{Kosaka2009PrognosticIO,
  title={Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma.},
  author={Takayuki Kosaka and Yasushi Yatabe and Ryoichi Onozato and Hiroyuki Kuwano and Tetsuya Mitsudomi},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2009},
  volume={4 1},
  pages={22-9}
}
INTRODUCTION Although mutation of the epidermal growth factor receptor (EGFR) gene is predictive for the response to EGFR-tyrosine kinase inhibitor, its prognostic impact for patients without EGFR-tyrosine kinase inhibitor treatment remains controversial. We examined for EGFR, KRAS or TP53 mutations in a consecutive large cohort of patients with lung adenocarcinoma, and evaluated their prognostic impact. METHODS We analyzed 397 patients with lung adenocarcinoma who underwent potentially… CONTINUE READING
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Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2008

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