Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer

@article{Lee2017PrognosticIO,
  title={Prognostic implication of CD274 (PD-L1) protein expression in tumor-infiltrating immune cells for microsatellite unstable and stable colorectal cancer},
  author={Kyu Sang Lee and Yoonjin Kwak and Soyeon Ahn and Eun Shin and Heung Kwon Oh and Duck-Woo Kim and S. Kang and Gheeyoung Choe and Woo Ho Kim and Hye Seung Lee},
  journal={Cancer Immunology, Immunotherapy},
  year={2017},
  volume={66},
  pages={927-939}
}
In this study, we investigated the clinical relevance of CD274 (PD-L1) protein expression by tumor cells and tumor-infiltrating immune cells in colorectal cancer (CRC). To this end, 186 microsatellite instability-high (MSI-H) and 153 microsatellite stable (MSS) CRCs were subjected to immunohistochemistry (IHC) analysis for the expression of CD274 and mismatch repair proteins. CD274 expression was evaluated in tumor cells at the center (TC) and periphery (TP), and immune cells at the center (IC… CONTINUE READING
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