Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer

  title={Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer},
  author={Benjamin Goeppert and Lena Frauenschuh and Manuela Zucknick and Albrecht Stenzinger and Mindaugas Andrulis and Frederick Klauschen and Korinna J{\"o}hrens and Arne Warth and Marcus Renner and Arianeb Mehrabi and Mohammadreza Hafezi and Armin Thelen and Peter Schirmacher and Wilko Weichert},
  booktitle={British Journal of Cancer},
Background:Biliary tract cancers (BTC) are relatively rare malignant tumours with poor prognosis. It is known from other solid neoplasms that antitumour inflammatory response has an impact on tumour behaviour and patient outcome. The aim of this study was to provide a comprehensive characterisation of antitumour inflammatory response in human BTC.Methods:Tumour-infiltrating T lymphocytes (CD4+, CD8+, and Foxp3+), natural killer cells (perforin+), B lymphocytes (CD20+), macrophages (CD68+) as… CONTINUE READING


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