Prognostic impact of matrix metalloproteinases (MMP-9 and MMP-2) and vascular endothelial growth factor expression in non-small cell lung cancer

Abstract

Aim: To investigate the role of matrix metalloproteinases (MMPs), MMP-9 and MMP-2, and vascular endothelial growth factor (VEGF) in metastasis and their relationship with survival. Early metastasis is the most common cause of lung cancer death. Angiogenesis and basement membrane damage are necessary for growth and invasion of the tumoral cells. VEGF, involved in angiogenic activity, and MMPs, involved in matrix destruction, are important for metastasis in lung cancer.

6 Figures and Tables

Cite this paper

@inproceedings{ztrk2012PrognosticIO, title={Prognostic impact of matrix metalloproteinases (MMP-9 and MMP-2) and vascular endothelial growth factor expression in non-small cell lung cancer}, author={Can {\"{O}zt{\"{u}rk and Ahmet Selim Yurdakul and Nal{\^a}n Aky{\"{u}rek and Şenay G{\"{o}r{\"{u}c{\"{u} Yilmaz and Jale Karakaya and Leyla Memiş}, year={2012} }