Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival.

@article{Donnem2009PrognosticIO,
  title={Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival.},
  author={Tom Donnem and Khalid I. Al-Shibli and Samer Al-Saad and L. T. Busund and Roy Martin Bremnes},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2009},
  volume={4 5},
  pages={
          578-85
        }
}
PURPOSE Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis. Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor-B (PDGF-B) as well as FGF2 and vascular endothelial growth factor-3 (VEGFR-3). This study investigates the prognostic impact of FGF2 and FGFR-1 in tumor cells and tumor stroma of resected non-small cell lung carcinomas (NSCLC… CONTINUE READING
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