Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia.

@article{Kern2004PrognosticIO,
  title={Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia.},
  author={Wolfgang Kern and Daniela Voskova and Claudia Schoch and Susanne Schnittger and Wolfgang Hiddemann and Torsten Haferlach},
  journal={Haematologica},
  year={2004},
  volume={89 5},
  pages={528-40}
}
BACKGROUND AND OBJECTIVES Early response after induction therapy is an independent prognostic factor in acute myeloid leukemia (AML). We improved the identification of this parameter by implementing multiparameter flow cytometry to quantify bone marrow cells carrying leukemia-associated immunophenotypes (LAIP). DESIGN AND METHODS In 106 uniformly treated patients flow cytometric analyses were performed at diagnosis and one week after induction therapy (day 16). The log-difference between LAIP… CONTINUE READING
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