Prognostic impact of cyclooxygenase-2 in breast cancer.

  title={Prognostic impact of cyclooxygenase-2 in breast cancer.},
  author={Carsten Denkert and K. J. Winzer and Steffen Hauptmann},
  journal={Clinical breast cancer},
  volume={4 6},
Cyclooxygenase (COX)-2, an inducible isoform of cyclooxygenases, regulates the rapid production of high levels of prostaglandins during inflammation. Cyclooxygenase-2 is overexpressed in a variety of malignant tumors. This review discusses epidemiologic and preclinical data on the role of COX-2 in the development and progression of breast cancer, and it will focus on recent studies that investigate the prognostic role of COX-2 in breast cancer. In rodent tumor models it has been shown that… CONTINUE READING


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