Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.

Abstract

The KMT2E (MLL5) gene encodes a histone methyltransferase implicated in the positive control of genes related to haematopoiesis. Its close relationship with retinoic acid-induced granulopoiesis suggests that the deregulated expression of KMT2E might lead acute promyelocytic leukaemia (APL) blasts to become less susceptible to the conventional treatment… (More)
DOI: 10.1111/bjh.12921

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@article{LucenaAraujo2014PrognosticIO, title={Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.}, author={Antonio R Lucena-Araujo and Haesook T Kim and Rafael Henrique J{\'a}como and Raul Antonio M. Melo and Rosane Isabel Bittencourt and Ricardo Pasquini and Katia Bogia Barbosa Pagnano and Evandro Maranh{\~a}o Fagundes and Maria de Lourdes Chauffaille and Carlos S{\'e}rgio Chiattone and Ana Lima and Hau C. Kwaan and Robert P Gallagher and Charlotte Marie Niemeyer and Stanley L. Schrier and Martin S. Tallman and David J Grimwade and Arnold Ganser and Nancy Berliner and Raul C. Ribeiro and Francesco Lo-Coco and Bob L{\"o}wenberg and Miguel Acevedo Sanz and Eduardo M Rego}, journal={British journal of haematology}, year={2014}, volume={166 4}, pages={540-9} }