Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index.

@article{Lauwers2002PrognosticHI,
  title={Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index.},
  author={Gregory Yves Lauwers and Beno{\^i}t Terris and Ulysses J. Balis and Kenneth P. Batts and J-M Regimbeau and Yuchiao Chang and Fiona Graeme-Cook and Hirohiko Yamabe and Iwao Ikai and Karen R. Cleary and Shiro Fujita and Jean-François Fl{\'e}jou and Lawrence R. Zukerberg and David M. Nagorney and Jacques Belghiti and Yoshio Yamaoka and J. Nicholas Vauthey},
  journal={The American journal of surgical pathology},
  year={2002},
  volume={26 1},
  pages={
          25-34
        }
}
Despite growing information on the clinical behavior of hepatocellular carcinoma, the histologic features associated with survival are not well characterized. Clinical and pathologic data on 425 patients who underwent complete resection for hepatocellular carcinoma were reviewed. Six microscopic features, namely, microvascular invasion, nuclear pleomorphism, mitosis, tumor architecture, growth interface, and tumor necrosis, were examined. Independent predictors of survival were identified and… CONTINUE READING
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