Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region.

@article{Passler2004PrognosticFO,
  title={Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region.},
  author={Christian Passler and Christian Scheuba and Gerhard Prager and Klaus Kaczirek and Klaus Kaserer and G. Zettinig and Bruno Niederle},
  journal={Endocrine-related cancer},
  year={2004},
  volume={11 1},
  pages={
          131-9
        }
}
Papillary (PTC) and follicular thyroid carcinoma (FTC) are known as differentiated thyroid carcinoma (DTC). Nevertheless, according to the UICC/AJCC (TNM) classification PTC and FTC are frequently analyzed as one cancer. The aim of this study is to show differences in outcome and specific prognostic factors in an iodine-replete endemic goiter region. Six hundred and three patients with DTC treated within a 35-year-period were retrospectively analyzed with respect to carcinoma-specific survival… 

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References

SHOWING 1-10 OF 75 REFERENCES

Application of Staging Systems for Differentiated Thyroid Carcinoma in an Endemic Goiter Region With Iodine Substitution

By applying staging systems in an endemic goiter region with iodine substitution, the best prognostic information for papillary thyroid carcinoma has been achieved with the MACIS score, while for follicular thyroid carcinomas the EORTC score and the UICC/AJCC system have the best predictive accuracy.

Pathological tumor-node-metastasis (pTNM) staging for papillary and follicular thyroid carcinomas: a retrospective analysis of 700 patients.

The TNM classification is useful in distinguishing patients with different prognostic outcomes, however, the small patient numbers in pTNM stages other than stages I precludes it from evaluating its usefulness as a guide for therapy.

Extent of surgery for intermediate-risk well-differentiated thyroid cancer.

Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer

In conclusion, lymph node metastases with a significant incidence at a young age and male sex had a substantial effect on survival and recurrence especially in those with tumor status T1–T3.

Papillary thyroid carcinoma: a multivariate analysis of prognostic factors including an evaluation of the p-TNM staging system.

The identification of sex in the multivariate analysis as a strong independent predictor of death of papillary thyroid cancer suggests that the prognostic value of the age related p-TNM staging system could be improved if sex was adjusted for, and if a different age was used for men and women.

Papillary thyroid carcinoma: prognostic index for survival including the histological variety.

The histological variety of PTC has prognostic value for survival in patients with PTC and a new prognostic index (PI) for survival can be formulated by accounting for these factors.

Prognostic Implications of the Tall Cell Variant of Papillary Thyroid Carcinoma

Results show that TCV of papillary thyroid carcinoma has a more aggressive clinical course and a worse prognosis than UPTC in patient groups with similar age and sex distributions, length of follow-up, and tumor size.

Prognostic factors in differentiated carcinoma of the thyroid gland.

Importance of Lymph Node Metastases in Follicular Thyroid Cancer

The data demonstrate lymph node metastases to be a significant prognostic factor for recurrence of FTC and the patient’s survival and advocate thyroidectomy plus central lymph node dissection as the basic surgical strategy.
...