Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients.

@article{Spiegelman1989PrognosticFI,
  title={Prognostic factors in small-cell carcinoma of the lung: an analysis of 1,521 patients.},
  author={Donna Spiegelman and L Herbert Maurer and James H. Ware and Michael C. Perry and A. Phillippe Chahinian and Robert Comis and William Eaton and Basil G. Zimmer and Mark D Green},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1989},
  volume={7 3},
  pages={344-54}
}
Cancer and Leukemia Group B (CALGB) accrued 1,745 patients with limited (LD) or extensive (ED) small-cell lung cancer (SCCL) to five separate trials between 1972 and 1986. We reviewed these data to evaluate the impact of pretreatment prognostic factors on outcome. In multivariate analysis, female gender was predictive of improved response (LD, P = .01; ED, P = .04) and survival (LD, P = .01; ED, P = .02). A performance status of 0 or 1 was associated with improved response rates in both subsets… CONTINUE READING
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