Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer

  title={Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer},
  author={Chen-Ping Hsieh and Jui-Ying Fu and Yun-hen Liu and Cheng-Ta Yang and Ming-Ju Hsieh and Ying Huang Tsai and Yi-cheng Wu and Ching-Yang Wu},
  journal={Biomedical Journal},
  pages={329 - 335}
Background: N2-positive non-small cell lung cancer (NSCLC) exhibits extremely low survival rates. The role of surgery in operable locally advanced N2 NSCLC remains controversial. In this study, we tried to analyze the role of surgery in resectable N2 NSCLC and the relationship between survival and clinico-pathologic factors from a pathologic point of view. Methods: 108 resectable pathologic N2-positive NSCLC patients, diagnosed from January 2005 to July 2012, were enrolled in this study. We… 

Figures and Tables from this paper

Survival benefit of skip metastases in surgically resected N2 non-small cell lung cancer: A multicenter observational study of a large cohort of the Chinese patients.
  • Xin LiXiaofei Li Xun Zhang
  • Medicine
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2019
Lymph node ratio is a prognostic factor for non-small cell lung cancer
This meta-analysis indicated that LNR was an independent predictor of survival in patients with NSCLC, and was significantly associated with decreased OS and DSS.
Prognostic value of lymph node ratio in non-small-cell lung cancer: a meta-analysis.
Patients with lower lymph node ratio was associated with better survival, indicating that lymph nodes ratio may be a promising prognostic predictor in non-small-cell lung cancer.
Alternative methods of lymph node staging in lung cancer: a narrative review.
It was showed that the present nodal staging may not accurately categorize every lung cancer patient and the number of positive lymph nodes and lymph node ratio or the log odds of positive node ratio are more legitimate, as they possess very robust data and should be considered initially as additional factors that can be incorporated in ongoing nodal staged systems.
Autonomic nervous infiltration positively correlates with pathological risk grading and poor prognosis in patients with lung adenocarcinoma
The relationship between autonomic nervous densities, pathological risk grading, and prognosis in patients with lung adenocarcinoma (LADC) is evaluated.
The Impact of Skip vs. Non-Skip N2 Lymph Node Metastasis on the Prognosis of Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis
This meta-analysis suggests that the prognosis of skip N2 lymph node metastases NSCLC is better than that of a non-skip N1 lymph node.
Lessons from the Drosophila microbiota
This issue of the Biomedical Journal includes two reviews discussing how studying the gut of the humble fruit fly can reveal important insight about our own microbial communities. In addition, we


Factors determining survival in resected N2 lung cancer.
Treatment strategy for patients with surgically discovered N2 stage IIIA non-small cell lung cancer.
Value of the Metastatic Lymph Node Ratio for Predicting the Prognosis of Non-Small-Cell Lung Cancer Patients
The combination of the LNR and pN status provides a valuable help with prognosis and could efficiently predicted outcomes of patients with lymph node-positive NSCLC.
Skip metastases: analysis of their clinical significance and prognosis in the IIIA stage of non-small cell lung cancer.
The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis.
Intra-tumoral vascular or perineural invasion as prognostic factors for long-term survival in early stage non-small cell lung carcinoma.