Prognostic factors in Paget's disease of the vulva: a study of 21 cases.

@article{Crawford1999PrognosticFI,
  title={Prognostic factors in Paget's disease of the vulva: a study of 21 cases.},
  author={David E. Crawford and Michael W Nimmo and Philip B. Clement and T. Harvey Thomson and Juliane Benedet and Dianne Miller and Cyril Blake Gilks},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={1999},
  volume={18 4},
  pages={
          351-9
        }
}
Twenty-one cases of vulvar Paget's disease were studied to assess possible prognostic indicators, including presence and depth of invasion, status of resection margins, tumor DNA cell content, and immunoreactivity for p53 and estrogen receptor proteins. Immunostaining for cytokeratin 7 (CK7), cytokeratin 20 (CK20), and gross cystic disease fluid protein-15 (GCDFP) were also performed. Patients were 45 to 82 years of age (mean, 66.9 years). Ten of 21 patients (47.6%) had invasive Paget's disease… CONTINUE READING
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