Prognostic factors for multiple myeloma in the dog.

  title={Prognostic factors for multiple myeloma in the dog.},
  author={Robert E. Matus and Cynthia Leifer and E. Gregory Macewen and Ariel Hurvitz},
  journal={Journal of the American Veterinary Medical Association},
  volume={188 11},
Multiple myeloma was diagnosed in 60 dogs. Diagnosis was confirmed in each case by observation of greater than 5% plasma cells on examination of a bone marrow aspirate and detection of monoclonal gammopathy of immunoglobulin (Ig) A or IgG. Treatment with melphalan, cyclophosphamide, and prednisone was associated with long-term survival (median, 540 days). Response to therapy was significantly related to prognosis (P less than 0.01), whereas hypercalcemia and Ig light chain proteinuria (Bence… CONTINUE READING