Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer.

Abstract

OBJECTIVE The purpose of this study was to evaluate the role of surgical staging in patients with grade 1 endometrioid uterine cancer. STUDY DESIGN Data were extracted from Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Kaplan-Meier and Cox proportional hazards analyses were used to determine predictors for disease-specific survival. RESULTS Twelve thousand seven hundred and twelve women were reported with endometrioid carcinoma, including 3867 with grade 1 disease, of which 25.5% had stage IC or more advanced disease, 15.4% with disease extending beyond the uterine corpus, 7.3% with extrauterine metastases, and 3.3% with lymph node metastases. On multivariate analysis, younger age and earlier stage remained as significant prognostic factors for improved survival. CONCLUSION Since grade 1 endometrioid uterine cancers have a 15.4% risk of extrauterine spread, a complete surgical staging procedure is recommended when clinically feasible. Younger age and earlier stage are significant prognostic factors for improved survival.

DOI: 10.1016/j.ajog.2007.08.028
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@article{Chan2008PrognosticFA, title={Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer.}, author={John K. C. Chan and Daniel S. Kapp and Michael Cheung and Jacob Y Shin and Deirdre Stieglitz and Amreen Husain and Nelson N. H. Teng and Jonathan S. Berek and Kathryn Elizabeth Osann and Hongyan Guo}, journal={American journal of obstetrics and gynecology}, year={2008}, volume={198 2}, pages={216.e1-5} }