Prognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancer

@article{Lazaridis2014PrognosticAP,
  title={Prognostic and predictive value of p-Akt, EGFR, and p-mTOR in early breast cancer},
  author={Georgios Lazaridis and Sofia Lambaki and Georgia Karayannopoulou and Anastasia G. Eleftheraki and Irene Papaspirou and Mattheos Bobos and Ioannis Efstratiou and George Pentheroudakis and Nikolaos Zamboglou and George Fountzilas},
  journal={Strahlentherapie und Onkologie},
  year={2014},
  volume={190},
  pages={636-645}
}
Background and purposeThere are scarce data available on the prognostic/predictive value of p-Akt and p-mTOR protein expression in patients with high-risk early breast cancer.Patients and methodsFormalin-fixed paraffin-embedded (FFPE) tumor tissue samples from 997 patients participating in two adjuvant phase III trials were assessed for EGFR, PTEN, p-Akt, p-mTOR protein expression, and PIK3CA mutational status. These markers were evaluated for associations with each other and with selected… CONTINUE READING

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