Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?

@inproceedings{Palmerini2015PrognosticAP,
  title={Prognostic and predictive role of CXCR4, IGF-1R and Ezrin expression in localized synovial sarcoma: is chemotaxis important to tumor response?},
  author={Emanuela Palmerini and Maria Serena Benassi and Irene Quattrini and L. Pazzaglia and Davide Maria Donati and Stefania Benini and Gabriella Gamberi and Marco Gambarotti and Piero Picci and Stefano Ferrari},
  booktitle={Orphanet journal of rare diseases},
  year={2015}
}
BackgroundSynovial sarcoma (SS) is a rare tumor, with dismal survival when metastatic. The role of adjuvant chemotherapy is debated. New prognostic and predictive factors are needed.MethodsWe reviewed patients with localized SS; SS18-SSX fusion transcript presence was confirmed by FISH and RT-PCR. Expression of CXCR4, IGF-1R and Ezrin were evaluated by immunohistochemistry.ResultsTumor samples from 88 SS patients (45 female; 43 male) with median age 37 years (range 11–63) were selected. The… CONTINUE READING
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