Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer.

@article{Tsao2007PrognosticAP,
  title={Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer.},
  author={Ming-Sound Tsao and Sarit Aviel-Ronen and K aiyang Ding and Davina Lau and Ni Liu and Akira Sakurada and Marlo Whitehead and Chang-Qi Zhu and Robert Burr Livingston and David Lloyd Johnson and James R. Rigas and Lesley Katie Seymour and Timothy L Winton and Frances A. Shepherd},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2007},
  volume={25 33},
  pages={
          5240-7
        }
}
PURPOSE p53 and RAS are multifunctional proteins that are critical to cell cycle regulation, apoptosis, cell survival, gene transcription, response to stress, and DNA repair. We have evaluated the prognostic and predictive value of p53 gene/protein aberrations using tumor samples from JBR.10, a North American phase III intergroup trial that randomly assigned 482 patients with completely resected stage IB and II non-small-cell lung cancer (NSCLC) to receive four cycles of adjuvant cisplatin plus… CONTINUE READING
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