Prognostic and predictive impact of central necrosis and fibrosis in early breast cancer: Results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy

@article{Maiorano2009PrognosticAP,
  title={Prognostic and predictive impact of central necrosis and fibrosis in early breast cancer: Results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy},
  author={Eugenio Maiorano and Meredith M. Regan and Giuseppe Viale and Mauro Giuseppe Mastropasqua and Marco Colleoni and Monica Castiglione-Gertsch and Karen N. Price and Richard D. Gelber and Aron Goldhirsch and Alan S. Coates},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={121},
  pages={211-218}
}
A minority of early invasive breast cancers show a pattern of central necrosis and fibrosis (CNF). Previous studies have documented an adverse prognostic impact and association with other adverse pathological features, but its predictive importance for therapy selection is unknown. We examined the prognostic and predictive value of CNF in two randomized clinical trials comparing chemoendocrine therapy with endocrine therapy alone in patients with node-negative breast cancer. A total of 1,850… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

405–411

EY Tan, M Yan, Campo L et al The key hypoxia regulated gene CAIX is upr tumours, is associated with resistance to chemotherapy. Br J C 100
doi:10.1038/sj.bjc.6604844 218 Breast Cancer Res Treat • 2010

Gene expression profiles associated with the presence of a fibrotic focus and the growth pattern in lymph node-negative breast cancer

GG Van den Eynden, M Smid, SJ van Laere
Clin Cancer Res 14:2944–2952 • 2008
View 1 Excerpt

Predictive value of tumor Ki67 expression in two randomized trials of adjuvant chemoendocrine therapy for nodenegative breast can

GG VandenEynden, CG Colpaert, A Couvelard
J Natl Cancer Inst • 2008

Similar Papers

Loading similar papers…