Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma

Abstract

Previous reports demonstrated the aberrant somatic hypermutation (SHM) of proto-oncogenes PIM-1, MYC, RhoH and PAX5 as a novel mechanism of genetic lesion in diffuse large B-cell lymphoma (DLBCL). The Rho family of small GTPases including Rho, Rac, and Cdc42 has been well characterized as molecular switches to transduce signals from plasma membrane to the… (More)
DOI: 10.1038/sj.leu.2404717

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