Prognostic Value of the Expression of Tumor Suppressor Genes p53, p21, p16 and pRb, and Ki-67 Labelling in High Grade Astrocytomas Treated with Radiotherapy

@article{Kirla2000PrognosticVO,
  title={Prognostic Value of the Expression of Tumor Suppressor Genes p53, p21, p16 and pRb, and Ki-67 Labelling in High Grade Astrocytomas Treated with Radiotherapy},
  author={Ruut M Kirla and Eeva K Salminen and Sakke Huhtala and Joanne Nuutinen and Lauri A I Talve and Hannu Kalervo Haapasalo and Hannu O. Kalimo},
  journal={Journal of Neuro-Oncology},
  year={2000},
  volume={46},
  pages={71-80}
}
Cumulative inactivation of tumor suppressor genes and/or amplification of oncogenes lead to progressively more malignant astrocytic tumors. We have analyzed the significance of tumor suppressor genes p53, p21, p16 and retinoblastoma protein (pRb) and proliferative activity for survival in 77 high grade astrocytic tumors. After operation, the patients – 25 anaplastic astrocytomas (AA) and 52 glioblastomas (GBs) – were treated with similar radiotherapy. The expression of the suppressor genes and… CONTINUE READING
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