Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis

  title={Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis},
  author={Eric M. Thompson and Thomas Hielscher and Eric Bouffet and Marc Remke and Betty Luu and Sridharan Gururangan and Roger E McLendon and Darell D Bigner and Eric S. Lipp and S{\'e}bastien Perreault and Y J Cho and Gerald Grant and Seung-Ki Kim and Seung-Ki Lee and Amulya A. Nageswara Rao and Caterina Giannini and Kay Ka Wai Li and Ho Keung Ng and Yu Yao and T Kumabe and Teiji Tominaga and Wieslawa Grajkowska and Marta Perek-Polnik and David C. Y. Low and Wan Tew Seow and Kenneth T. E. Chang and Jaume Mora and Ian F Pollack and Ronald L. Hamilton and Sarah E S Leary and Andrew S Moore and Wendy J Ingram and Andrew R. Hallahan and Anne Jouvet and Mich{\`e}lle F{\`e}vre-Montange and Alexandre Vasiljevic and C{\'e}cile Faure-Conter and Tomoko Shofuda and Naoki Kagawa and Naoya Hashimoto and Nada Jabado and A G Weil and Tenzin Gayden and Takafumi Wataya and Tarek Shalaby and Michael Andreas Grotzer and Karel Zitterbart and Jaroslav Sterba and Leo{\vs} Křen and Tibor Hortob{\'a}gyi and A'lmos Klekner and Bogn{\'a}r L{\'a}szl{\'o} and T{\'i}mea P{\'o}cza and P{\'e}ter Hauser and Ulrich Sch{\"u}ller and Shin Chul Jung and Woo-Youl Jang and Pim J French and Johan M. Kros and Marie-Lise Charlotte van Veelen and Luca Massimi and Jeffrey Leonard and Joshua B Rubin and Rajeev Vibhakar and Lola B. Chambless and J. Gerardo Valadez and R. Campbell Thompson and Cl{\'a}udia Dutra Costantin Faria and Alice Duarte de Carvalho and Sofia G. Nunes and Jos{\'e} F{\'e}lix Oletta Pimentel and Xing Fan and Karin M. Muraszko and Enrique L{\'o}pez-Aguilar and David Lyden and Livia Garzia and David J. H. Shih and Noriyuki Kijima and Christian Schneider and Jennifer Adamski and Paul A. Northcott and Marcel Kool and D T W Jones and Jennifer A W Chan and Ana Nediljka Nikoli{\'c} and Maria L Garr{\`e} and Erwin G Van Meir and Satoru Osuka and Jeffrey John Olson and Arman Jahangiri and Brandyn A. Castro and Nalin Gupta and William A. Weiss and Iska Moxon-Emre and Donald J Mabbott and Alvaro Lassaletta and Cynthia Elaine Hawkins and Uri Tabori and James M. Drake and Abhaya V Kulkarni and Peter Dirks and Kullervo Hynynen and Andrey Korshunov and Stefan M. Pfister and Roger J. Packer and Vijay Ramaswamy and Michael D Taylor},
  booktitle={The Lancet. Oncology},
BACKGROUND Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. METHODS We… CONTINUE READING

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  • 2014