Prognostic Significance of Peripheral Blood Flow Cytometry Parameters for Breast Cancer

Abstract

Breast cancer (BC) is the most common cancer and the second most common cause of mortality in women due to cancer (Siegel et al., 2011). It is a heterogeneous disease that encompasses a variety of clinical patterns, biological behaviors, prognostic characteristics, and responses to different types of treatment (Simpson et al., 2005). Ambitious efforts have been made to improve overall survival (OS) and morbidity by early diagnosis and multiple therapies (Curigliano et al., 2007). However, we need to define new prognostic tools and develop highly targeted therapies (Emens et al., 2004). Immune functions and their relation to prognosis in cancer patients is an area of great interest for many researchers in recent years (Domschke et al., 2009). A study revealed that the preoperative expression levels of cluster of differentiation (CD) of the CD3+, CD4+/CD8+ and NK+ cells in patients with colorectal cancer was positively correlated with prognosis (Wang et al., 1999). Also a study indicated that CD4+/CD8+ ratio may be accepted as an objective indicator to evaluate the prognosis of gastric cancer (GC) patients, a lower ratio means higher risk of local recurrence and distant metastasis and poor prognosis (Rey-Ferro et al., 1997). CD4+, CD8+ expression levels in patients with esophageal cancer was positively correlated with survival

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Cite this paper

@inproceedings{Engin2014PrognosticSO, title={Prognostic Significance of Peripheral Blood Flow Cytometry Parameters for Breast Cancer}, author={H{\"{u}seyin B{\"{u}lent Engin and Cemil Bilir and Ishak Ozel Tekin}, year={2014} }