Prognostic Significance of NOTCH1 and FBXW7 Mutations in Pediatric T-ALL

@inproceedings{Erbilgin2010PrognosticSO,
  title={Prognostic Significance of NOTCH1 and FBXW7 Mutations in Pediatric T-ALL},
  author={Yucel Erbilgin and Muge Sayitoglu and Ozden Hatirnaz and {\"O}mer Doğru and A. Adnan Akçay and Gulen Tuysuz and Tiraje T{\"u}lin Celkan and Gonul Aydogan and Zafer Şalcioğlu and Çetin Timur and Lebriz Yuksel-Soycan and Umit Barbaros Ure and Sema Anak and Leyla Ağaoğlu and Omer Devecioğlu and Inci Yildiz and Uğur {\"O}zbek},
  booktitle={Disease markers},
  year={2010}
}
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T-ALL patients. In this study, the mutation analysis of NOTCH1 and FBXW7 genes was performed in 87 pediatric T-ALLs who were treated on the ALL-BFM… CONTINUE READING

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