Prognostic Significance of Capn4 Overexpression in Intrahepatic Cholangiocarcinoma

  title={Prognostic Significance of Capn4 Overexpression in Intrahepatic Cholangiocarcinoma},
  author={Chi Zhang and Dou-sheng Bai and Xiao-Yong Huang and Guo-Ming Shi and Ai-Wu Ke and Liu-Xiao Yang and Xin-Rong Yang and Jian Zhou and Jia Fan},
  booktitle={PloS one},
BACKGROUND Calpain small subunit 1 (Capn4) has been shown to correlate with the metastasis/invasion of hepatocellular carcinoma. This study aimed to investigate the role of Capn4 in intrahepatic cholangiocarcinoma (ICC). METHODS Capn4 expression was measured in 33 ICC tissues by quantitative real-time polymerase chain reaction and western blot. The role of Capn4 in the migration, invasion and proliferation of ICC cells and matrix metalloproteinase 2 (MMP2) expression were assessed after Capn4… CONTINUE READING
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