Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis

@article{Lin2018PrognosticRO,
  title={Prognostic Role of Platelet-to-Lymphocyte Ratio in Hepatocellular Carcinoma with Different BCLC Stages: A Systematic Review and Meta-Analysis},
  author={Wanfu Lin and Mao-Feng Zhong and Yu-Ren Zhang and Huan Wang and Hetong Zhao and Bin-Bin Cheng and C. Ling},
  journal={Gastroenterology Research and Practice},
  year={2018},
  volume={2018}
}
The role of platelet-to-lymphocyte ratio (PLR) in the prognosis of hepatocellular carcinoma (HCC) patients with different Barcelona Clinic Liver Cancer (BCLC) stages remains controversial. This systematic review and meta-analysis aimed to determine the efficacy of PLR on HCC prognosis. Five electronic databases were searched for clinical trials focusing on the role of PLR in the prognosis of HCC. A total of 297 potential studies were initially identified, and 9 studies comprising 2449 patients… Expand
Prognostic significance of platelet-to-lymphocyte ratio in urothelial carcinoma patients: a meta-analysis
TLDR
A significant correlation between elevated PLR and poor prognosis in UC was demonstrated and the prognostic role of PLR may help guide the management and prognostication of UC patients. Expand
Prognostic Roles of Blood Inflammatory Markers in Hepatocellular Carcinoma Patients Taking Sorafenib. A Systematic Review and Meta-Analysis
TLDR
The pooled results showed that the synthesized HR favored patients with low pretreatment NLR (neutrophil-to-lymphocyte ratio), which indicated that HCC patients with a lower baseline NLR may have a better response to sorafenib than those with higher NLR, andInterestingly, the predictive effect on OS (overall survival) was more pronounced as the NLR cutoff value increased. Expand
Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma
TLDR
The preoperative NLR-PLR is predictive of both OS and RFS in patients with HCC undergoing curative liver resection, validate combined preoperative Neutrophil-to-Lymphocyte ratio (NLR) and PLR in predicting overall survival and recurrence free survival in patients who underwent curative resection for HCC. Expand
Comparison of Platelet to Lymphocyte Ratio between Degrees of the Barcelona Clinic Liver Cancer on Hepatocellular Carcinoma Patients at Haji Adam Malik General Hospital
TLDR
There were differences in PLR levels with various BCLC stages in patients with HCC at Haji Adam Malik Hospital during 2015-2016, which is associated with aggressive HCC behaviour. Expand
Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Outcomes in Patients With Unresectable Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Plus Sorafenib
  • Lei Zhang, Zhi-Ping Yan, +8 authors Qiang Li
  • Medicine
  • Frontiers in Molecular Biosciences
  • 2021
TLDR
The prognostic value of quantitative inflammatory biomarkers in correlation with OS and PFS in unresectable HCC patients undergoing TACE plus sorafenib treatment was shown. Expand
Prognostic significance of inflammatory indices in hepatocellular carcinoma treated with transarterial chemoembolization: A systematic review and meta-analysis
TLDR
Elevated preoperative NLR, PLR, and CRP are associated with poor prognosis in HCC patients treated with TACE and these inflammatory indices may be convenient, accessible, affordable and dependable biomarkers with prognostic potential for H CC patients treated by TACE. Expand
Pre/Post-Treatment Dynamic of Inflammatory Markers Has Prognostic Value in Patients with Small Hepatocellular Carcinoma Managed by Stereotactic Body Radiation Therapy
TLDR
High post-treatment PLR and change in NLR ≥2.7-fold were associated with poor prognosis in patients treated with SBRT and might be considered as reliable and independent prognostic biomarkers for patients with sHCC. Expand
Albumin-to-Alkaline Phosphatase Ratio Associates with Good Prognosis of Hepatitis B Virus-Positive HCC Patients
TLDR
AAPR shows promise as a reliable prognostic factor in patients with hepatitis B virus-related HCC after curative hepatectomy, which could be used as a routine inspection of HCC patients before surgery. Expand
Integrated liver inflammatory score predicts the therapeutic outcome of patients with hepatocellular carcinoma after transarterial chemoembolization.
TLDR
ILIS is a powerful prognostic index for survival of HCC patients after TACE, suggesting that pretreatment ILIS should be considered during the patient evaluation process. Expand
The prognostic significance of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in giant cell tumor of the extremities
TLDR
As a novel inflammatory index, NLR has some predictive power for the prognosis of patients with giant cell tumor of the extremities. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 79 REFERENCES
Prognostic role of platelet to lymphocyte ratio in esophageal cancer: A meta-analysis
TLDR
It is suggested that PLR might be a significant predicative biomarker of poor prognosis for esophageal cancer patients. Expand
Preoperative platelet lymphocyte ratio as independent predictors of prognosis in pancreatic cancer: A systematic review and meta-analysis
TLDR
The preoperative platelet to lymphocyte ratio may be a significant independent prognostic factor in patients with pancreatic cancer and is found to predict oncologic outcomes in multiple malignancies. Expand
Preoperative platelet-to-lymphocyte ratio is a valuable prognostic biomarker in patients with hepatocellular carcinoma undergoing curative liver resection
  • Hao Yang, Jinghang Jiang, +5 authors B. Xiang
  • Medicine
  • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • 2017
TLDR
E Elevated preoperative PLR may be independently associated with poor OS and DFS in HCC patients following curative resection after curative liver resection. Expand
The Prognostic Value of Platelet-to-Lymphocyte Ratio in Urological Cancers: A Meta-Analysis
TLDR
Elevated PLR was negatively related to the OS of patients with urological cancers, except in BCa, and more large scale prospective studies with high quality are required in the future. Expand
The platelet-to-lymphocyte ratio predicts poor survival in patients with huge hepatocellular carcinoma that received transarterial chemoembolization
TLDR
For patients with huge HCC, a high baseline PLR is a useful predictor of poor survival in patients undergoing chemoembolization, and additional anti-inflammatory or anti-platelet treatments, in combination with TACE, may improve survival in HCC patients with high PLR. Expand
Predictive value of pre-transplant platelet to lymphocyte ratio for hepatocellular carcinoma recurrence after liver transplantation
TLDR
Pre-trans transplant PLR ≥125 was associated with advanced tumor stage and aggressive tumor behavior, and it can be used as a prognostic factor for post-transplant HCC recurrence. Expand
Prognostic Nutritional Index (PNI) Predicts Tumor Recurrence of Very Early/Early Stage Hepatocellular Carcinoma After Surgical Resection
TLDR
The PNI is a significant prognostic factor for OS and DFS of patients with very early/early stage HCC receiving curative surgery, and an independent predictor for disease-specific death, and early and late tumor relapses. Expand
Assessment of the relationship between neutrophil lymphocyte ratio and prognostic factors in non-metastatic colorectal cancer.
TLDR
The study showed that a high neutrophil-lymphocyte ratio had an adverse effect on overall survival in colorectal cancer patients who had a curative surgery, but it could not establish any association between neutrophils or lymphocytes ratio and the factors such as lymphovascular invasion, perineural invasion, tumor size expect hemoglobin and serum albumin levels. Expand
Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab.
TLDR
Elevated pre-treatment NLR and PLR are associated with shorter OS and PFS and with lower response rates in patients with metastatic NSCLC treated with nivolumab independently of other prognostic factors. Expand
Inflammation scores predict the survival of patients with hepatocellular carcinoma who were treated with transarterial chemoembolization and recombinant human type-5 adenovirus H101
TLDR
The NLR-PLR score is a more powerful predictive system than the other inflammation-based scores for patients with HCC who were treated with TACE and H101, and the predictive ability may be improved by utilizing a combination of the NLR -PLR and CLIP scores. Expand
...
1
2
3
4
5
...