Prognostic Impact of Renin–Angiotensin System Blockade on Renal Cell Carcinoma After Surgery

@article{Miyajima2015PrognosticIO,
  title={Prognostic Impact of Renin–Angiotensin System Blockade on Renal Cell Carcinoma After Surgery},
  author={Akira Miyajima and Satoshi Yazawa and Takeo Kosaka and Nobuyuki Tanaka and Suguru Shirotake and Ryuichi Mizuno and Eiji Kikuchi and Mototsugu Oya},
  journal={Annals of Surgical Oncology},
  year={2015},
  volume={22},
  pages={3751-3759}
}
Angiotensin 2 is a key biologic peptide in the renin–angiotensin system (RAS) that regulates blood pressure and renal hemodynamics. The potential role of the RAS in the promotion of tumor growth, angiogenesis, and metastasis also has been shown in the past few decades. This study investigated the prognostic impact of RAS blockade on patients with renal cell carcinoma (RCC) after surgery. The study identified 557 patients with pathologically diagnosed RCC (pT1-4 N0M0) and evaluated the… CONTINUE READING
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