Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.

  title={Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor.},
  author={Anna Karpathakis and Harpreet K Dibra and Chistodoulos Pipinikas and Andrew Feber and Tiffany J. Morris and Joshua M. Francis and Dahmane Oukrif and Dalvinder S Mandair and Marinos Pericleous and Mullan Mohmaduvesh and Stefano Serra and Olagunju Ogunbiyi and Marco R. Novelli and T Luong and Sylvia L Asa and Matthew H. Kulke and Christos G Toumpanakis and Tim Meyer and Martyn Evan Caplin and Matthew L Meyerson and Stephan Beck and Christina Thirlwell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={22 1},
PURPOSE Small intestinal neuroendocrine tumors (SINET) are the commonest malignancy of the small intestine; however, underlying pathogenic mechanisms remain poorly characterized. Whole-genome and -exome sequencing has demonstrated that SINETs are mutationally quiet, with the most frequent known mutation in the cyclin-dependent kinase inhibitor 1B gene (CDKN1B) occurring in only ∼8% of tumors, suggesting that alternative mechanisms may drive tumorigenesis. The aim of this study is to perform… CONTINUE READING
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Global hypomethylation and promoter methylation in small Clin Cancer Res

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