Prognostic Impact of [18F]Fluorothymidine and [18F]Fluoro-D-Glucose Baseline Uptakes in Patients with Lung Cancer Treated First-Line with Erlotinib

  title={Prognostic Impact of [18F]Fluorothymidine and [18F]Fluoro-D-Glucose Baseline Uptakes in Patients with Lung Cancer Treated First-Line with Erlotinib},
  author={Matthias Scheffler and Thomas Zander and Lucia Nogov{\'a} and Carsten Kobe and Deniz Kahraman and Markus Dietlein and Irini Papachristou and Lukas Heukamp and Reinhard Buettner and Ron Boellaard and Adriaan A. Lammertsma and Silvia Querings and Erich Stoelben and Walburga Engel-Riedel and Bernd Neumaier and J{\"u}rgen Wolf},
  booktitle={PloS one},
UNLABELLED 3'-deoxy-3'-[(18)F]fluoro-L-thymidine (FLT) and 2'-deoxy-2'-[(18)F]fluoro-D-glucose (FDG) are used to visualize proliferative and metabolic activity of tumors. In this study we aimed at evaluating the prognostic value of FLT and FDG uptake measured by positron emission tomography (PET) in patients with metastatic non-small cell lung cancer (NSCLC) prior to systemic therapy with erlotinib. FLT and FDG maximum standardized uptake (SUVmax) values per patient were analyzed in 40… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Modeling tumor dynamics and overall survival in advanced non-small-cell lung cancer treated with erlotinib.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2015


Publications referenced by this paper.
Showing 1-10 of 51 references

Marked, homogeneous, and early [18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2012
View 13 Excerpts
Highly Influenced

Comparison of 18F-FLT PET and 18F-FDG PET in esophageal cancer.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine • 2005
View 2 Excerpts
Highly Influenced

[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2012