Prognostic Effect of Epithelial and Stromal Lymphocyte Infiltration in Non–Small Cell Lung Cancer

@article{AlShibli2008PrognosticEO,
  title={Prognostic Effect of Epithelial and Stromal Lymphocyte Infiltration in Non–Small Cell Lung Cancer},
  author={Khalid I. Al-Shibli and Tom D{\o}nnem and Samer Al-Saad and Magnus Persson and Roy Martin Bremnes and L. T. Busund},
  journal={Clinical Cancer Research},
  year={2008},
  volume={14},
  pages={5220 - 5227}
}
Purpose: The major value of prognostic markers in potentially curable non-small cell lung cancer (NSCLC) should be to guide therapy after surgical resection. In this regard, the patients' immune status at the time of resection may be important and also measurable. The immune system has paradoxical roles during cancer development. However, the prognostic significance of tumor-infiltrating lymphocytes is controversial. The aim of this study is to elucidate the prognostic significance of… 

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References

SHOWING 1-10 OF 57 REFERENCES
Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma
TLDR
It is demonstrated for the first time that increased numbers of CTLs at the invasive border may be a reliable independent prognostic factor of survival in patients with endometrial carcinoma.
Prognostic markers in resectable non-small cell lung cancer: a multivariate analysis.
TLDR
AJCC stage remains the most important prognostic indicator from a variety of clinical variables and tumour markers in postoperative patients with resectable NSCLC, and the presence of peritumoral B lymphocytes was strongly associated with improved survival, suggesting an important role for humoral mediated immunity.
Inverse Prognostic Impact of Angiogenic Marker Expression in Tumor Cells versus Stromal Cells in Non–Small Cell Lung Cancer
TLDR
These are the first tissue microarray data in non–small cell lung cancers showing a positive prognostic impact by highly expressed angiogenic markers in tumor stroma, with VEGF-C as a major independent prognostic indicator.
Concurrent infiltration by CD8+ T cells and CD4+ T cells is a favourable prognostic factor in non-small-cell lung carcinoma
TLDR
The presence of high levels of both CD8+ T cells and CD4- T cells is a significant indicator of a better prognosis for patients with NSCLC, and cooperation between these cell populations may allow a significantly more potent antitumour response than either population alone.
Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas.
TLDR
The presence of CD8(+) T cell infiltration in esophageal carcinomas is a favorable prognostic factor that should have diagnostic and therapeutic implications.
CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.
TLDR
The data suggested that human colorectal cancer tissue was infiltrated by various numbers of T cells that had cytotoxic phenotype, contributing to a better survival of patients, and could be a novel prognostic factor.
Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression.
TLDR
It was concluded that, in NSCLC, TIL cytotoxicity is likely to be low because of a poor class I MHC expression by tumor cells, and TAM low production of cytotoxic cytokines is a major limit to their possible cytot toxic activity.
CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non‐small cell lung cancers
TLDR
Investigation of intratumoral tumor‐infiltrating lymphocytes in non‐small cell lung cancers and their relationships with clinicopathological variables and post‐operative survival found higher labeling index of Ki‐67/CD8+ T cells within cancer cell nests is a strong indicator of unfavorable clinical outcome.
Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma
TLDR
The data indicate that, despite HLA-haplotype loss a vigorous antitumor immune response mediated by CD8+ T-cells can be present in NSCLC offering possibilities for specific immunotherapy.
...
...