Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection

  title={Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection},
  author={Shannon M. Fernando and Alexandre Tran and Monica Taljaard and Wei Cheng and Bram Rochwerg and Andrew J. E. Seely and Jeffrey J Perry},
  journal={Annals of Internal Medicine},
Despite substantial advances in treatment, sepsis remains a major cause of morbidity and mortality worldwide (1, 2). In the emergency department (ED), patients with infection and sepsis are an enormous burden: An estimated 850000 visits occur annually in the United States (3). Similarly, patients admitted to hospital wards with infection are at risk for clinical deterioration, sepsis or septic shock, and even death (4). Rapid identification of patients with sepsis and early initiation of… 
Sepsis and Septic Shock Definitions in Patients With Cancer Admitted in ICU
The new definition of sepsis and septic shock is applicable in an ICU oncological population with the same reliability as in the general population and is more accurate than qSOFA and SIRS criteria to predict hospital mortality.
The Quick Sepsis-related Organ Failure Assessment Score in Brazil: Insights for Future Use in Diverse Settings
  • K. DeMerleK. Rudd
  • Medicine
    American Journal of Respiratory and Critical Care Medicine
  • 2020
This large, multicenter, prospective study evaluated two patient cohorts and reported the predictive accuracy of the qSOFA score for hospital mortality in adult, non-ICU patients in Brazil from May 2016 to March 2017.
The early use of sepsis scores to predict respiratory failure and mortality in non-ICU patients with COVID-19
Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
Multivariate prediction scores, such as SOFA and NEWS, had greater prognostic accuracy than qSOFA or SIRS for hospital mortality, ICU transfer, and ICU length of stay and complex sepsis scores may offer enhanced prognostic performance as compared to simple sepsi scores in inpatient hospital settings where more complex scores can be readily calculated.
Quick sequential organ failure assessment versus systemic inflammatory response syndrome criteria for emergency department patients with suspected infection
To predict in-hospital mortality in patients visiting to the emergency department with suspected infection, qSOFA was demonstrated to be modestly more accurate than the SIRS criteria albeit insufficiently sensitive.
Development of a clinical prediction rule for sepsis in primary care: protocol for the TeSD-IT study
A clinical prediction rule for the recognition of sepsis in a high-risk primary care setting to aid in the decision which patients have to be immediately referred to a hospital and who can be safely treated at home is developed.
Predictive Accuracy of the Quick Sepsis-related Organ Failure Assessment Score in Brazil. A Prospective Multicenter Study
A qSOFA score greater than or equal to 2 has low sensitivity for predicting death in patients with suspected infection in a developing country and being used as a screening tool for sepsis may miss patients who ultimately die.


Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department
Among patients presenting to the emergency department with suspected infection, the use of qSOFA resulted in greater prognostic accuracy for in-hospital mortality than did either SIRS or severe sepsis, and these findings provide support for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria in theEmergency department setting.
Assessment of Sepsis-3 criteria and quick SOFA in patients with cirrhosis and bacterial infections
Sepsis-3 criteria are more accurate than SIRS criteria in predicting the severity of infections in patients with cirrhosis and qSOFA is a useful bedside tool to assess risk for worse outcomes in these patients.
Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection*
Emergency department patients with suspected infection and low quick Sequential Organ Failure Assessment scores frequently receive critical care interventions, and the misclassification of these patients as “low risk,” in combination with the low sensitivity of quick sequential organ Failure Assessment greater than or equal to 2, may diminish the clinical utility of thequick Sequential organ failure assessment score.
Time to Treatment and Mortality during Mandated Emergency Care for Sepsis
More rapid completion of a 3‐hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completed of an initial bolus of intravenous fluids, were associated with lower risk‐adjusted in‐hospital mortality.
Evaluation of definitions for sepsis.
Sepsis is a complex clinical entity that could be viewed as a continuum with substantial variation in initial severity and risk of hospital death and is the continuous measure of hospital mortality risk estimated primarily from physiologic abnormalities.
The most commonly used disease severity scores are inappropriate for risk stratification of older emergency department sepsis patients: an observational multi-centre study
The prognostic and discriminative performance of the five most commonly used disease severity scores was poor and less useful for risk stratification of older ED sepsis patients.
Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit
In patients with suspected infection who eventually required admission to the ICU, qSOFA calculated before their ICU admission had greater accuracy than SIRS for predicting mortality and ICU-free days, however, it may be less clear whetherqSOFA is also better than S IRS criteria for predicting ventilator free-days and organ dysfunction- free days.
Development of a Simple Sequential Organ Failure Assessment Score for Risk Assessment of Emergency Department Patients With Sepsis
Simple SOFA demonstrates similar predictive ability for in-hospital mortality from sepsis compared to SOFA, which is complex and unfamiliar to most emergency physicians.