Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling

  title={Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling},
  author={Alain J Barrier and François Roser and Pierre-Yves Bo{\"e}lle and Brigitte Franc and Chantal Ts{\'e} and Didier Brault and François Lacaine and Sidney Houry and Patrice Callard and Christophe Penna and Brigitte Debuire and Antoine Flahault and Sandrine Dudoit and Antoinette Lemoine},
We have assessed the possibility to build a prognosis predictor (PP), based on non-neoplastic mucosa microarray gene expression measures, for stage II colon cancer patients. Non-neoplastic colonic mucosa mRNA samples from 24 patients (10 with a metachronous metastasis, 14 with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. Patients were repeatedly and randomly divided into 1000 training sets (TSs) of size 16 and validation sets (VS) of size 8. For each TS/VS split, a 70… CONTINUE READING


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