Prognosis of children with virus-associated hemophagocytic syndrome and malignant histiocytosis: correlation with levels of serum interleukin-1 and tumor necrosis factor.

@article{Ishii1991PrognosisOC,
  title={Prognosis of children with virus-associated hemophagocytic syndrome and malignant histiocytosis: correlation with levels of serum interleukin-1 and tumor necrosis factor.},
  author={Eiichi Ishii and Shouichi Ohga and Tomonobu Aoki and Sayuri Yamada and Masahiro Sako and Hideko Tasaka and Atsutoshi Kuwano and Masato Sasaki and Yukiko Tsunematsu and Kyoji Ueda},
  journal={Acta haematologica},
  year={1991},
  volume={85 2},
  pages={93-9}
}
To clarify the correlation of cytokine level with the severity and prognosis of children with the hemophagocytic syndrome, we analyzed serum interleukin-1 (IL-1) and tumor necrosis factor (TNF) levels in 26 children with either the virus-associated hemophagocytic syndrome (VAHS, n = 12) or malignant histiocytosis (MH, n = 14). When compared to healthy controls, 13 children had an elevated IL-1 (greater than or equal to 20 pg/ml) and 21 children had an elevated TNF (greater than or equal to 10… CONTINUE READING
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