Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission.

@article{Yanada2012PrognosisOA,
  title={Prognosis of acute myeloid leukemia harboring monosomal karyotype in patients treated with or without allogeneic hematopoietic cell transplantation after achieving complete remission.},
  author={Masamitsu Yanada and Saiko Kurosawa and Takuhiro Yamaguchi and Takuya Yamashita and Yukiyoshi Moriuchi and Hiroatsu Ago and Jin Takeuchi and Hirohisa Nakamae and Jun Taguchi and Toru Sakura and Yasushi Takamatsu and Fusako Waki and Hiroki Yokoyama and Masato Watanabe and Nobuhiko Emi and Takahiro Fukuda},
  journal={Haematologica},
  year={2012},
  volume={97 6},
  pages={915-8}
}
To evaluate the prognostic impact of monosomal karyotype on post-remission outcome in acute myeloid leukemia, we retrospectively analyzed 2,099 patients who had achieved complete remission. Monosomal karyotype was noted in 73 patients (4%). Of these, the probability of overall survival from first complete remission was 14% at four years, which was significantly lower than that reported in patients without monosomal karyotype, primarily due to a high relapse rate (86%). Monosomal karyotype… CONTINUE READING

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