Prognosis in chronic myeloid leukaemia: biology of the disease vs. treatment.

@article{Sokal1987PrognosisIC,
  title={Prognosis in chronic myeloid leukaemia: biology of the disease vs. treatment.},
  author={Joseph E. Sokal},
  journal={Bailliere's clinical haematology},
  year={1987},
  volume={1 4},
  pages={907-29}
}
CML is best regarded as a benign neoplasm, which regularly transforms into a rapidly fatal malignant one. Survival is determined by the timing of disease transformation. The rate of transformation and death is low initially and increases gradually to a stable annual rate, reached during the third year after diagnosis. This averages 25% per year in large populations of Ph positive patients. Transformation appears to occur randomly; a patient's risk of transformation can be defined, but the time… CONTINUE READING

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