Prognosis Methylation of p 16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia : A Prospective Cohort Study

Abstract

Purpose: Inactivation of p16 gene by CpG methylation is a frequent event in oral epithelial dysplasia. To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospective cohort study. Experimental Design: One hundred one patients with histologically confirmed mild or moderate oral… (More)

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