Proglumide prevents and curtails acute tolerance to morphine in rats

  title={Proglumide prevents and curtails acute tolerance to morphine in rats},
  author={J. Tang and J. Chou and Michael J. Iadarola and H. -Y. T. Yang and Erminio Costa},
CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat
Evidence is provided that chronic treatment with a selective CCKB receptor antagonist could prevent tolerance to the analgesic effect of morphine without affecting morphine‐induced physical dependence and by eliminating the need to increase morphine doses to unacceptable levels.


Peptide inhibitor of morphine- and beta-endorphin-induced analgesia.
The synthetic beta-endorphin analogs with the omission of the NH2-terminal [Met]enkephalin segment are shown to inhibit morphine- or beta-Endorphin-induced analgesia in mice by the tail-flick test, raising the possibility that endogenous inhibiting peptides exist in the brain which play a role in the regulation of endorphin actions.
Proglumide: selective antagonism of excitatory effects of cholecystokinin in central nervous system.
Intravenous and iontophoretic proglumide administration consistently blocked cholecystokinin-induced excitations while having no effect on glutamic acid-induced increases in activity, suggesting that this drug may be valuable for studying the possible role of chole Cytokine as a neurotransmitter or neuromodulator in the central nervous system.
Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia.
A physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems is suggested and a similar mode of action may explain other behavioral effects of chole CyStokinin, such as suppression of food intake.
Effects of Pro‐Leu‐Gly‐NH2 (MIF) on the antinociceptive and thermoregulatory actions of morphine and oxotremorine
Recently, it was demonstrated that MIF antagonizes morphine's antinociceptive action when given chronically to rats (Dickinson & Slater 1980), and more data is presented on chronic MIF and morphine's thermoregulatory and antinOCiceptive actions.
Possible interaction between cholecystokinin and dopamine.