Proglumide prevents and curtails acute tolerance to morphine in rats

@article{Tang1984ProglumidePA,
  title={Proglumide prevents and curtails acute tolerance to morphine in rats},
  author={J. Tang and J. Chou and Michael J. Iadarola and H. -Y. T. Yang and Erminio Costa},
  journal={Neuropharmacology},
  year={1984},
  volume={23},
  pages={715-718}
}
CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat
TLDR
Evidence is provided that chronic treatment with a selective CCKB receptor antagonist could prevent tolerance to the analgesic effect of morphine without affecting morphine‐induced physical dependence and by eliminating the need to increase morphine doses to unacceptable levels.
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