Proglumide prevents and curtails acute tolerance to morphine in rats

@article{Tang1984ProglumidePA,
  title={Proglumide prevents and curtails acute tolerance to morphine in rats},
  author={J. Tang and J. Chou and Michael J. Iadarola and H. -Y. T. Yang and Erminio Costa},
  journal={Neuropharmacology},
  year={1984},
  volume={23},
  pages={715-718}
}
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81 Citations
Background Citations
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Results Citations
1

81 Citations

Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718.
Cholecystokinin receptor binding in morphine analgesia: Tolerance, withdrawal and abstinence
Caerulein changes morphine-induced antinociception depending on pretreatment times.
Dissociation of tolerance and dependence to morphine: a possible role for cholecystokinin
Chronic administration of cholecystokinin antagonists reverses the enhancement of spinal morphine analgesia induced by acute pretreatment
CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the rat
TLDR
Evidence is provided that chronic treatment with a selective CCKB receptor antagonist could prevent tolerance to the analgesic effect of morphine without affecting morphine‐induced physical dependence and by eliminating the need to increase morphine doses to unacceptable levels.
Caerulein-induced antinociception: Interaction with morphine and opioid antagonists in the rat
The Role of Cholecystokinin Antagonists in Human Pain Management: A Review
Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions
Spinal co-administration of cholecystokinin antagonists with morphine prevents the development of opioid tolerance
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