Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.

@article{Drucker1989ProglucagonGE,
  title={Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.},
  author={Daniel J Drucker and Patricia L Brubaker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 11},
  pages={3953-7}
}
Expression of the gene encoding preproglucagon gives rise to different glucagon-related peptides in the pancreas and intestine. Glucagon gene expression is regulated by a protein kinase C-dependent pathway in rat islet cell lines, whereas activation of the adenylate cyclase pathway in islet cell lines is without effect. To elucidate the factors important… CONTINUE READING