Proglucagon-derived peptides in intestinal epithelial proliferation: glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats.

@article{Ghatei2001ProglucagonderivedPI,
  title={Proglucagon-derived peptides in intestinal epithelial proliferation: glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats.},
  author={Mohammad A. Ghatei and Robert A. Goodlad and Shahrad Taheri and Nikki Mandir and Audrey E. Brynes and Mark Jordinson and Stephen R. Bloom},
  journal={Digestive diseases and sciences},
  year={2001},
  volume={46 6},
  pages={1255-63}
}
Proglucagon-derived peptides have been implicated in the control of intestinal mucosal cell division. To investigate the actions of these peptides on intestinal cell proliferation, different doses of enteroglucagon, oxyntomodulin, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) were tested in male Wistar rats maintained on total parenteral nutrition. Crypt cell proliferation was assessed by the analysis of arrested metaphases in microdissected crypts. Enteroglucagon and… CONTINUE READING

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