Progestogens with Antiandrogenic Properties

@article{Raudrant2012ProgestogensWA,
  title={Progestogens with Antiandrogenic Properties},
  author={D. Raudrant and T. Rabe},
  journal={Drugs},
  year={2012},
  volume={63},
  pages={463-492}
}
Chlormadinone acetate, cyproterone acetate and dienogest are potent, orally active progestogens, which have antiandrogenic instead of partial androgenic activity. They act mainly by blocking androgen receptors in target organs, but also reduce the activity of skin 5α-reductase, the enzyme responsible for converting testosterone to the more potent androgen, 5α-dihydrotestosterone, in sebaceous glands and hair follicles. Chlormadinone acetate and cyproterone acetate also suppress gonadotropin… Expand
View on Springer
ncbi.nlm.nih.gov
83 Citations
Background Citations
24
Methods Citations
2

83 Citations

Citation Type

Citation Type

Profile of the progesterone derivative chlormadinone acetate - pharmocodynamic properties and therapeutic applications.
Profile of the progesterone derivative chlormadinone acetate - pharmocodynamic properties and therapeutic applications.
Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17α-ethinylestradiol (EE2), and their mixtures: Transactivation with human and rainbowfish hormone receptors and transcriptional effects in zebrafish (Danio rerio) eleuthero-embryos.
Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: II. Clinical effects.
Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects.
Use of oral contraceptives in the management of acne
Endocrinological, metabolic and clinical features of treatment with oral contraceptive formulation containing ethinylestradiol plus chlormadinone acetate in nonobese women with polycystic ovary syndrome.
Evaluation of different antiandrogenic progestins on clinical and biochemical variables in polycystic ovary syndrome
Effect of chlormadinone acetate versus drospirenone-containing oral contraceptives on the endocrinal features of women with polycystic ovary syndrome: Systematic review and meta-analysis of randomized clinical trials.
Ethinylestradio-Chlormadinone Acetate Combination for the Treatment of Hirsutism and Hormonal Alterations of Normal-Weight Women With Polycystic Ovary Syndrome: Evaluation of the Metabolic Impact
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 188 REFERENCES
[Effect of ethinyl estradiol-dienogest combination on serum androgen concentrations].
Inhibition of skin 5α-reductase by oral contraceptive progestins in vitro
Antifertility effects of low dose progestin.
Comparative Pharmacology of Newer Progestogens
Antiandrogens in the treatment of acne and hirsutism.
Effects on acne of two oral contraceptives containing desogestrel and cyproterone acetate.
A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women
Effect of the progestogens, gestodene, 3-keto desogestrel, levonorgestrel, norethisterone and norgestimate on the oxidation of ethinyloestradiol and other substrates by human liver microsomes
Can oral contraceptive steroids influence the elimination of nifedipine and its primary pryidine metabolite in humans?
Androgens and Therapeutic Aspects of Antiandrogens in Women
...
1
2
3
4
5
...