Progestogens with Antiandrogenic Properties

@article{Raudrant2012ProgestogensWA,
  title={Progestogens with Antiandrogenic Properties},
  author={D. Raudrant and T. Rabe},
  journal={Drugs},
  year={2012},
  volume={63},
  pages={463-492}
}
Chlormadinone acetate, cyproterone acetate and dienogest are potent, orally active progestogens, which have antiandrogenic instead of partial androgenic activity. They act mainly by blocking androgen receptors in target organs, but also reduce the activity of skin 5α-reductase, the enzyme responsible for converting testosterone to the more potent androgen, 5α-dihydrotestosterone, in sebaceous glands and hair follicles. Chlormadinone acetate and cyproterone acetate also suppress gonadotropin… Expand
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