Progestogens with Antiandrogenic Properties
@article{Raudrant2012ProgestogensWA, title={Progestogens with Antiandrogenic Properties}, author={Daniel Raudrant and Thomas Rabe}, journal={Drugs}, year={2012}, volume={63}, pages={463-492} }
Chlormadinone acetate, cyproterone acetate and dienogest are potent, orally active progestogens, which have antiandrogenic instead of partial androgenic activity. They act mainly by blocking androgen receptors in target organs, but also reduce the activity of skin 5α-reductase, the enzyme responsible for converting testosterone to the more potent androgen, 5α-dihydrotestosterone, in sebaceous glands and hair follicles. Chlormadinone acetate and cyproterone acetate also suppress gonadotropin…
94 Citations
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DNG exerted an important stimulatory effect on sex hormone-binding globulin (SHBG) and biochemical markers of hyperandrogenism as well as dehydroepiandrosterone sulphate and total testosterone in women with polycystic ovary syndrome.
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As expected, the most common menstrual disturbances were breakthrough bleeding, spotting and amenorrhoea, and EE/CMA was well tolerated in clinical trials and the postmarketing surveillance studies.
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