Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.
- Biology, MedicineEndocrine reviews
The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials, and the recognition that progesterone is synthesized by neurons and glial cells requires a reevaluation of hormonal aging.
Estrogen-progestins and progestins for the management of endometriosis.
- Medicine, BiologyFertility and sterility
Combined estrogen-progestogen contraceptives
- Medicine, Biology
A variety of innovations have been developed since combined hormonal contraceptives were first available in the late 1950s, including changes in drug components, doses used, and the temporal sequencing of exposure to drugs.
Certain Progestins Prevent the Enhancing Effect of 17β-Estradiol on NO-Mediated Inhibition of Platelet Aggregation by Endothelial Cells
- Biology, MedicineArteriosclerosis, thrombosis, and vascular biology
Certain progestins, including MPA, attenuate the 17β-E–induced NO-mediated inhibition of platelet aggregation by endothelial cells through preventing both eNOS and GTPCH I expression most likely via activation of glucocorticoid receptors.
Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys
- Biology, MedicineBreast Cancer Research and Treatment
Oral micronized progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate, and both progestogens significantly attenuated E2 effects on body weight, endometrium, and the TFF1 marker of estrogen receptor activity in the breast.
Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data
- Medicine, BiologyMolecular and Cellular Endocrinology
The effect of medroxyprogesterone acetate on estrogen-dependent risks and benefits – an attempt to interpret the Women's Health Initiative results
- Medicine, BiologyGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
In contrast, CEE alone reduced non-significantly the risk of CHD in women aged 50–59 years, suggesting that primary prevention is possible if estrogen replacement therapy is initiated early.
Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology
- Medicine, BiologyInternational journal of endocrinology
Overall, EE20/LNG100 combination is safe and well tolerated, and in several studies the incidence of adverse events in the treated group was comparable to that of the placebo group.
TREATMENT OF OSTEOPOROSIS
- Biology, Medicine
Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons
- BiologyMolecular and Cellular Endocrinology
SHOWING 1-10 OF 87 REFERENCES
The Role and Use of Progestogens
- MedicineObstetrics and gynecology
Based upon the available literature, it is believed that the enthusiasm for continuous combined therapy is premature and caution is urged in its use until further, more conclusive, data become available.
Endometrial safety of hormone replacement therapy: review of literature.
Drospirenone: pharmacology and pharmacokinetics of a unique progestogen.
- Biology, MedicineContraception
A comparison of the potencies and activities of progestogens used in contraceptives.
- Medicine, BiologyContraception
Effects of hormone replacement therapy on the endometrium and lipid parameters: a review of randomized clinical trials, 1985 to 1995.
- MedicineAmerican journal of obstetrics and gynecology
The effects of progestins on vasomotor flushes.
- MedicineThe Journal of reproductive medicine
It is hoped that as more physicians begin to add medroxyprogesterone acetate to the estrogen regimen to reduce the risk of endometrial hyperplasia, it might be that a lower dose of estrogen will be necessary to relieve flushes.
Effect of progestin therapy on cortical and trabecular bone: comparison with estrogen.
- Medicine, BiologyThe American journal of medicine
Effects of Hormone Replacement Therapy on Endometrial Histology in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
Combining CEE with cyclic or continuous MPA or cyclic MP protected the endometrium from hyperplastic changes associated with estrogen-only therapy.