Progestogen safety and tolerance in hormonal replacement therapy
@article{Palacios2016ProgestogenSA, title={Progestogen safety and tolerance in hormonal replacement therapy}, author={Santiago Palacios and Andrea Mej{\'i}a}, journal={Expert Opinion on Drug Safety}, year={2016}, volume={15}, pages={1515 - 1525} }
ABSTRACT Introduction: Today, it is a mandatory practice to prescribe a combination of estrogens and progestogens for menopausal women requiring hormone therapy and with a uterus. The WHI study and its reanalysis demonstrate a big difference in results between the conjugated equin estrogen (CEE) only vs.CEE plus medroxyprogesterone acetate (MPA) arms in relation with breast cancer and cardiovascular risk. The conclusion is that risk is clearly higher in the arm with MPA than in the CEE only arm…
14 Citations
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References
SHOWING 1-10 OF 113 REFERENCES
Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.
- Medicine, BiologyEndocrine reviews
- 2013
Differences in chemical structure, metabolism, pharmacokinetics, affinity, potency, and efficacy via steroid receptors, intracellular action, and biological and clinical effects confirm the absence of a class effect of progestogens.
Role of progestogen in hormone therapy for postmenopausal women: position statement of The North American Menopause Society.
- MedicineMenopause
- 2003
Progestogen should be added to ET for all postmenopausal women with an intact uterus to prevent the elevated risk of estrogen-induced endometrial hyperplasia and adenocarcinoma.
Controversies concerning the safety of estrogen replacement therapy
- MedicineAmerican journal of obstetrics and gynecology
- 1987
Progestin may modify the effect of low-dose hormone therapy on mammographic breast density
- MedicineClimacteric : the journal of the International Menopause Society
- 2009
Although hormone therapy appears to suspend breast involution, it does not increase breast density in the majority of treated women, and progestins differing in pharmacological properties may have a variable impact on breast density.
Potency of progestogens used in hormonal therapy: Toward understanding differential actions
- Biology, MedicineThe Journal of Steroid Biochemistry and Molecular Biology
- 2014
The levonorgestrel intrauterine system in menopausal hormone replacement therapy: five-year experience.
- MedicineFertility and sterility
- 1999
Estrogen plus progestin and the risk of coronary heart disease.
- Medicine, BiologyThe New England journal of medicine
- 2003
Estrogen plus progestin does not confer cardiac protection and may increase the risk of CHD among generally healthy postmenopausal women, especially during the first year after the initiation of hormone use.
Symptom Relief and Side Effects of Postmenopausal Hormones: Results From the Postmenopausal Estrogen/Progestin Interventions Trial
- MedicineObstetrics and gynecology
- 1998
Effects of Hormone Replacement Therapy on Endometrial Histology in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
- Medicine
- 1996
Combining CEE with cyclic or continuous MPA or cyclic MP protected the endometrium from hyperplastic changes associated with estrogen-only therapy.
Short-term and long-term effects of tibolone in postmenopausal women.
- MedicineThe Cochrane database of systematic reviews
- 2016
Evaluating the effectiveness and safety of tibolone for treatment of postmenopausal and perimenopausal women found it was more effective than placebo and associated with greater likelihood of bleeding, which suggests that if 18% of women taking placebo experience unscheduled bleeding, between 31% and 44% ofWomen taking tiblone will do so.