Progestogen-related gross and microscopic changes in female Beagles.

@article{Nelson1976ProgestogenrelatedGA,
  title={Progestogen-related gross and microscopic changes in female Beagles.},
  author={Lindemann Nelson and William A. Kelly},
  journal={Veterinary pathology},
  year={1976},
  volume={13 2},
  pages={143-56}
}
Long-term studies of megestrol acetate and chlormadinone acetate in 100 female dogs are in progress. Doses of zero, one, 10 and 25 times the expected human dose of megestrol acetate and 25 times the expected human dose of chlormadinone acetate (on a milligram per kilogram body weight basis) are being given daily. During the first 4 years, eight dogs from each of the five groups were killed. The principal gross findings included enlarged uteri with mucoid material in the lumina, mammary… CONTINUE READING

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