Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones

  title={Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones},
  author={Renate Louw-du Toit and Karl-Heinz Storbeck and Meghan Cartwright and Angelique Cabral and Donita J Africander},
  journal={Molecular and Cellular Endocrinology},
Steroidogenesis refers to the de novo synthesis of steroid hormones from cholesterol by a number of sequential enzyme catalysed reactions in the adrenal and the gonads. In addition, circulating steroid hormone precursors are further metabolised in selected peripheral tissues. It has been suggested that the biosynthesis of endogenous steroid hormones can be modulated by progestins, used widely by women in female reproductive medicine. However, as a number of structurally diverse progestins with… 
10 Citations
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  • J. T. Sanderson
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    Toxicological sciences : an official journal of the Society of Toxicology
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