Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium.

Abstract

Menstruation, or cyclic shedding of nonpregnant endometrial tissue with associated bleeding, occurs only in humans and a few other species. This breakdown of the endometrium in response to falling ovarian progesterone levels is a complex process, characterized by local leukocyte infiltration, expression and activation of matrix metalloproteinases, and… (More)

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