Progestins inhibit murine oocyte meiotic maturation in vitro.

  title={Progestins inhibit murine oocyte meiotic maturation in vitro.},
  author={Candy Barrett and R. Douglas Powers},
  journal={The Journal of experimental zoology},
  volume={265 3},
The in vitro culture of fully grown mammalian oocytes results in spontaneous meiotic maturation from prophase arrest to metaphase II. This maturation can be inhibited by steroid hormones in both murine and porcine oocytes. Using selected steroids, we have examined the structure-activity relationships of steroids and oocyte inhibition. Experiments with androgens, estrogens, glucocorticoids, and progesterone revealed that at least one steroid from each class was inhibitory. Progesterone, however… CONTINUE READING