Progestins inhibit estradiol-induced vascular endothelial growth factor and stromal cell-derived factor 1 in human endometrial stromal cells.

@article{Okada2011ProgestinsIE,
  title={Progestins inhibit estradiol-induced vascular endothelial growth factor and stromal cell-derived factor 1 in human endometrial stromal cells.},
  author={Hidetaka Okada and Rika Okamoto and Tomoko Tsuzuki and Shoko Tsuji and Kaneki Yasuda and Hideharu Kanzaki},
  journal={Fertility and sterility},
  year={2011},
  volume={96 3},
  pages={
          786-91
        }
}
OBJECTIVE To investigate whether 17β-estradiol (E(2)) and progestins exert direct effects on vascular endothelial growth factor (VEGF) and stromal cell-derived factor 1 (SDF-1/CXCL12) in human endometrial stromal cells (ESCs) and thereby to clarify the regulatory function of these local angiogenic factors in the endometrium. DESIGN In vitro experiment. SETTING Research laboratory at Kansai Medical University. PATIENT(S) Fourteen patients undergoing hysterectomy for benign reasons… CONTINUE READING
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