Progestins block cholesterol synthesis to produce meiosis-activating sterols.

  title={Progestins block cholesterol synthesis to produce meiosis-activating sterols.},
  author={Bernhard Lindenthal and Anne L. Holleran and Tayseer A Aldaghlas and Benfang Ruan and George J. Schroepfer and William K. Wilson and Joanne K. Kelleher},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={15 3},
The resumption of meiosis is regulated by meiosis-preventing and meiosis-activating substances in testes and ovaries. Certain C29 precursors of cholesterol are present at elevated levels in gonadal tissue, but the mechanism by which these meiosis-activating sterols (MAS) accumulate has remained an unresolved question. Here we report that progestins alter cholesterol synthesis in HepG2 cells and rat testes to increase levels of major MAS (FF-MAS and T-MAS). These C29 sterols accumulated as a… CONTINUE READING


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